| Ellen Pompeo (Meredith Grey) | Patrick Dempsey (Derek Shepherd) | Justin Chambers (Alex Karev) | Katherine Heigl (Isobel "Izzie" Stevens) |
| T.R. Knight (George O'Malley) | Sandra Oh (Cristina Yang) | James Pickens Jr. (Richard Webber) | Chandra Wilson (Miranda Bailey) |
| Isaiah Washington (Dr. Preston Burke) | Kate Walsh | ||
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